The present investigation was aimed at investigating the potential of Pistacia Vera Linn. outer seed shell powder (PV-SSP) as superdisintegrant while formulating orodisperse exhibiting lowest disintegration time with enough mechanical strength. Interaction of piroxicam (PX) and β-cyclodextrin (β-CD) was investigated in solid state. Solubility studies demonstrated that the formation of PX- β-CD inclusion complex with 1:1 stoichiometry. Orodisperse prepared with PV-SSP (10% w/w) were directly compressible and showed superior disintegrating property due to decreased water sorption time, wetting time, increased water absorption ratio, without any significant change in swelling index. The mechanism of superdisintegration suggested that when PV-SSP used in formulation and compressed into tablet it get deformed and after contact in water these deformed particles get into their normal structure and produces a break-up of the tablet. The in-vitro release results displayed that orodispersible tablet containing PX- β-CD solid complex displayed faster PX release compared to those containing free drug. Thus, the findings signalled great potential for using PV-SSP as superdisintegrant in orodisperse with low disintegration time.
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